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| Latest Line | ||
| Over / Under | ||
| Season Record (NFL Rk) | 14-2-0 (1st) | 9-7-0 (13th) |
| Division Ranking | 1st | 2nd |
| Wild Card Ranking | 2nd | |
| Home Record (Rk) | 7-1-0 (3rd) | 4-4-0 (18th) |
| Away Record (Rk) | 7-1-0 (1st) | 5-3-0 (5th) |
| Overtime Record (Rk) | 0-0-0 (14th) | 0-0-0 (14th) |
| Record vs Division | 6-0-0 | 1-5-0 |
| Record vs Conference | 10-2-0 | 6-6-0 |
| Points For (Rk) | 416 (7th) | 388 (10th) |
| Points Against (Rk) | 307 (8th) | 333 (17th) |
| Last 10 Games | 8-2-0 | 6-4-0 |
| Current Streak | Lost 2 | Won 4 |
| | |
| Fantasy Points given up to QB's Avg (Rank) | 14.94 (9) | 15.57 (13) |
| Fantasy Points given up to RB's Avg (Rank) | 23.33 (22) | 21.91 (16) |
| Fantasy Points given up to WR's Avg (Rank) | 32.24 (28) | 25.6 (8) |
| Fantasy Points given up to TE's Avg (Rank) | 7.02 (1) | 11.04 (24) |
| Fantasy Points given up to K's Avg (Rank) | 6.75 (28) | 6.25 (22) |
| Fantasy Points given up to DL Avg (Rank) | 18.7 (1) | 27.85 (25) |
| Fantasy Points given up to LB's Avg (Rank) | 34.6 (2) | 37.4 (7) |
| Fantasy Points given up to DB's Avg (Rank) | 47.35 (12) | 52.55 (29) |
| Fantasy Points given up Per Game Avg (Rank) | 184.93 (7) | 198.18 (19) |
| Fantasy Points given up Total | 3698.55 | 3963.5 |
| | |
| Ht and Wt average Offensive linemen | 6-4, 301.8 | 6-4, 302.9 |
| Total yds/game | 363.1 (9th) | 383.1 (4th) |
| Total passing yds/game | 282.2 (2nd) | 290.9 (1st) |
| Total rushing yds/game | 80.9 (32nd) | 92.2 (30th) |
| Touchdowns (total) | 53 (4th) | 46 (T9th) |
| Touchdowns (passing) | 34 (T1st) | 29 (T5th) |
| Touchdowns (rushing) | 16 (T12th) | 13 (18th) |
| Touchdowns (returns) | 1 (T9th) | 1 (T9th) |
| Touchdowns (others) | 2 (T19th) | 3 (T8th) |
| Passing Attempts | Peyton Manning (571) | Matt Schaub (583) |
| Passing Completions | Peyton Manning (393) | Matt Schaub (396) |
| Passing Yards | Peyton Manning (4500) | Matt Schaub (4770) |
| Passing Longest | Peyton Manning (80) | Matt Schaub (72) |
| Passing Touchdowns | Peyton Manning (33) | Matt Schaub (29) |
| Rushing Carries | Joseph Addai (219) | Ryan Moats (101) |
| Rushing Yards | Joseph Addai (828) | Ryan Moats (390) |
| Rushing Longest | Donald Brown (45) | Arian Foster (24) |
| Rushing Touchdowns | Joseph Addai (10) | Ryan Moats (4) |
| Receiving Receptions | Reggie Wayne, Dallas Clark (100) | Andre Johnson (101) |
| Receiving Yards | Reggie Wayne (1264) | Andre Johnson (1569) |
| Receiving Longest | Dallas Clark (80) | Andre Johnson (72) |
| Receiving Touchdowns | Reggie Wayne, Dallas Clark (10) | Andre Johnson (9) |
| | |
| Ht and Wt average Defensive linemen | 6-3, 279.3 | 6-4, 291.1 |
| Opp. total yds/game | 339.3 (18th) | 325 (14th) |
| Opp. passing yds/game | 212.8 (14th) | 217.9 (18th) |
| Opp. rushing yds/game | 126.5 (25th) | 107.1 (11th) |
| Sacks | 34 (T14th) | 29 (25th) |
| Interceptions | 16 (15th) | 14 (T20th) |
| Sacks Sacks | Dwight Freeney (13.5) | Mario Williams (9) |
| Interceptions Interceptions | Antoine Bethea (4) | Bernard Pollard, Brian Cushing (4) |
| Interceptions Yards | Jacob Lacey (53) | Bernard Pollard (121) |
| Interceptions Longest | Jacob Lacey (35) | Bernard Pollard (70) |
| Interceptions Touchdowns | Clint Session, Jacob Lacey (1) | Bernard Pollard (1) |
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